Brief report: Chimerism and tolerance in a recipient of a deceased-donor liver transplant

被引：126

作者：

Alexander, Stephen I. ^{[1
,2
,3
]}

Smith, Neil ^{[2
,3
]}

Hu, Min ^{[1
]}

Verran, Deborah ^{[4
]}

Shun, Albert ^{[2
,3
,4
]}

Dorney, Stuart ^{[2
,3
,4
]}

Smith, Arabella ^{[2
,3
]}

Webster, Boyd ^{[2
,3
]}

Shaw, Peter John ^{[2
,3
]}

Lammi, Ahti ^{[2
,3
]}

Stormon, Michael O. ^{[2
,3
,4
]}

机构：

[1] Univ Sydney, Ctr Kidney Res, Sydney, NSW 2006, Australia

[2] Univ Sydney, Childrens Hosp Westmead, Sydney, NSW 2006, Australia

[3] Univ Sydney, Dept Paediat & Child Hlth, Sydney, NSW 2006, Australia

[4] Australian Natl Liver Transplant Unit, Sydney, NSW, Australia

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 04期

关键词：

D O I：

10.1056/NEJMoa0707255

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Complete hematopoietic chimerism and tolerance of a liver allograft from a deceased male donor developed in a 9- year- old girl, with no evidence of graft- versus- host disease 17 months after transplantation. The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy.

引用

页码：369 / 374

页数：6

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