Regioselective synthesis of 1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reactions in water

被引：110

作者：

Wang, ZX ^{[1
]}

Qin, HL ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 19期

关键词：

D O I：

10.1039/b307084k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of an arylacetylene with an azide in hot water gave 1,4-disubstituted 1,2,3-triazoles in high yields, while similar reaction between a terminal aliphatic alkyne and an azide (except m-nitroazidobenzene) afforded a mixture of regioisomers with the ratio of 1,4- to 1,5-isomers ranging from 3 : 1 to 28.6:1. Reactions of m-nitroazidobenzene with either arylalkynes or aliphatic alkynes formed only 1,4-disubstituted derivatives in excellent yields.

引用

页码：2450 / 2451

页数：2

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