学术探索
学术期刊
新闻热点
数据分析
智能评审

Hematopoietic stem and progenitor cells: Clinical and preclinical regeneration of the hematolymphoid system

被引：249
作者：
Shizuru, JA [1 ]
Negrin, RS
Weissman, IL
机构：
[1] Stanford Univ, Med Ctr, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA
[2] Stanford Univ, Med Ctr, Dept Pathol, Stanford, CA 94305 USA
来源：
ANNUAL REVIEW OF MEDICINE | 2005年 / 56卷
关键词：
bone marrow; embryonic stem cell; transplantation; cancer; autoimmune;
D O I：
10.1146/annurev.med.54.101601.152334
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A vast literature exists on the biology of blood formation and regeneration under experimental and clinical conditions. The field of hematopoiesis was recently advanced by the capacity to purify to homogeneity primitive hematopoietic stem and progenitor cells. Isolation of cells at defined maturational stages has enhanced the understanding of the fundamental nature of stem cells, including how cell fate decisions are made, and this understanding is relevant to the development of other normal as well as malignant tissues. This review updates the basic biology of hematopoietic stem cells (HSC) and progenitors, the evolving use of purified HSC as grafts for clinical hematopoietic cell transplantation (HCT) including immune tolerance induction, and the application of HSC biology to other stem cell fields.
引用
收藏
页码：509 / 538
页数：30
相关论文
共 188 条
  • [1] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    Akashi, K
    Traver, D
    Miyamoto, T
    Weissman, IL
    [J]. NATURE, 2000, 404 (6774) : 193 - 197
  • [2] Akashi K, 2001, HEMATOPOIESIS DEV AP, P15
  • [3] Prospective identification of tumorigenic breast cancer cells
    Al-Hajj, M
    Wicha, MS
    Benito-Hernandez, A
    Morrison, SJ
    Clarke, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
  • [4] Cell differentiation - Hepatocytes from nonhepatic adult stem cells
    Alison, MR
    Poulsom, R
    Jeffery, R
    Dhillon, AP
    Quaglia, A
    Jacob, J
    Novelli, M
    Prentice, G
    Williamson, J
    Wright, NA
    [J]. NATURE, 2000, 406 (6793) : 257 - 257
  • [5] Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    Allsopp, RC
    Morin, GB
    DePinho, R
    Harley, CB
    Weissman, IL
    [J]. BLOOD, 2003, 102 (02) : 517 - 520
  • [6] Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells
    Allsopp, RC
    Cheshier, S
    Weissman, IL
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (11) : 1427 - 1433
  • [7] HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    Antonchuk, J
    Sauvageau, G
    Humphries, RK
    [J]. CELL, 2002, 109 (01) : 39 - 45
  • [8] HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation
    Antonchuk, J
    Sauvageau, G
    Humphries, RK
    [J]. EXPERIMENTAL HEMATOLOGY, 2001, 29 (09) : 1125 - 1134
  • [9] Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation
    Arber, C
    BitMansour, A
    Sparer, TE
    Higgins, JP
    Mocarski, ES
    Weissman, IL
    Shizuru, JA
    Brown, JMY
    [J]. BLOOD, 2003, 102 (02) : 421 - 428
  • [10] SUCCESSFUL ALLOGENEIC TRANSPLANTATION OF T-CELL DEPLETED BONE-MARROW FROM CLOSELY HLA-MATCHED UNRELATED DONORS
    ASH, RC
    CASPER, JT
    CHITAMBAR, CR
    HANSEN, R
    BUNIN, N
    TRUITT, RL
    LAWTON, C
    MURRAY, K
    HUNTER, J
    BAXTERLOWE, LA
    GOTTSCHALL, JL
    OLDHAM, K
    ANDERSON, T
    CAMITTA, B
    MENITOVE, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (08) : 485 - 494
12345678910