Value and limitation of meta-analysis

被引:19
作者
Verstraete, M [1 ]
机构
[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium
关键词
D O I
10.1159/000073581
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Meta-analysis is a valuable method of aggregating data sets of different trials which are inadequate or unconvincing on their own. There are strict rules on the retrieval and selection of data which are crucial in terms of the validity of a meta-analysis. Many so-called meta-analyses are flawed because of lack of a protocol or non adherence to it. Also underreporting of clinical trials is haunting the validity of meta-analysis. This hidden information is not a random process but is affecting mainly trials with negative results. To avoid this publication bias all clinical trials should enter an international online database. Copyright 2002 S. Karger AG. Basel.
引用
收藏
页码:278 / 281
页数:4
相关论文
共 30 条
  • [1] [Anonymous], SYSTEMATIC REV HLTH
  • [2] BEROYZ G, 1994, LANCET, V343, P619
  • [3] CONSIDERATIONS FOR THE METAANALYSIS OF RANDOMIZED CLINICAL-TRIALS - SUMMARY OF A PANEL DISCUSSION
    BOISSEL, JP
    BLANCHARD, J
    PANAK, E
    PEYRIEUX, JC
    SACKS, H
    [J]. CONTROLLED CLINICAL TRIALS, 1989, 10 (03): : 254 - 281
  • [4] THE COCHRANE-COLLABORATION - PREPARING, MAINTAINING, AND DISSEMINATING SYSTEMATIC REVIEWS OF THE EFFECTS OF HEALTH-CARE
    CHALMERS, I
    [J]. DOING MORE GOOD THAN HARM: THE EVALUATION OF HEALTH CARE INTERVENTIONS, 1993, 703 : 156 - 165
  • [5] How can medical journals help prevent poor medical research? Some opportunities presented by electronic publishing
    Chalmers, I
    Altman, DG
    [J]. LANCET, 1999, 353 (9151) : 490 - 493
  • [6] METAANALYSIS OF CLINICAL-TRIALS AS A SCIENTIFIC DISCIPLINE .1. CONTROL OF BIAS AND COMPARISON WITH LARGE COOPERATIVE TRIALS
    CHALMERS, TC
    LEVIN, H
    SACKS, HS
    REITMAN, D
    BERRIER, J
    NAGALINGAM, R
    [J]. STATISTICS IN MEDICINE, 1987, 6 (03) : 315 - &
  • [7] COLLINS R, 1995, LANCET, V345, P669
  • [8] DEVITA C, 1994, LANCET, V343, P1115
  • [9] Dickersin K, 1997, AIDS EDUC PREV, V9, P15
  • [10] Uses and abuses of meta-analysis
    Egger, M
    Smith, GD
    Sterne, JAC
    [J]. CLINICAL MEDICINE, 2001, 1 (06) : 478 - 484