Value and limitation of meta-analysis

被引:19
作者
Verstraete, M [1 ]
机构
[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium
关键词
D O I
10.1159/000073581
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Meta-analysis is a valuable method of aggregating data sets of different trials which are inadequate or unconvincing on their own. There are strict rules on the retrieval and selection of data which are crucial in terms of the validity of a meta-analysis. Many so-called meta-analyses are flawed because of lack of a protocol or non adherence to it. Also underreporting of clinical trials is haunting the validity of meta-analysis. This hidden information is not a random process but is affecting mainly trials with negative results. To avoid this publication bias all clinical trials should enter an international online database. Copyright 2002 S. Karger AG. Basel.
引用
收藏
页码:278 / 281
页数:4
相关论文
共 30 条
  • [11] β Blockade after myocardial infarction:: systematic review and meta regression analysis
    Freemantle, N
    Cleland, J
    Young, P
    Mason, J
    Harrison, J
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1999, 318 (7200): : 1730 - 1737
  • [12] Time to register randomised trials
    Horton, R
    Smith, R
    [J]. LANCET, 1999, 354 (9185) : 1138 - 1139
  • [13] IMPERIALE TF, 1991, JAMA-J AM MED ASSOC, V266, P261
  • [14] Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials
    Ioannidis, JPA
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (04): : 281 - 286
  • [15] CUMULATIVE METAANALYSIS OF THERAPEUTIC TRIALS FOR MYOCARDIAL-INFARCTION
    LAU, J
    ANTMAN, EM
    JIMENEZSILVA, J
    KUPELNICK, B
    MOSTELLER, F
    CHALMERS, TC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (04) : 248 - 254
  • [16] Discrepancies between meta-analyses and subsequent large randomized, controlled trials
    LeLorier, J
    Gregoire, G
    Benhaddad, A
    Lapierre, J
    Derderian, F
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (08) : 536 - 542
  • [17] THE MEDICAL REVIEW ARTICLE - STATE OF THE SCIENCE
    MULROW, CD
    [J]. ANNALS OF INTERNAL MEDICINE, 1987, 106 (03) : 485 - 488
  • [18] SETTING LIMITS IN CLINICAL MEDICINE
    MURPHY, DJ
    POVAR, GJ
    PAWLSON, LG
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1994, 154 (05) : 505 - 512
  • [19] PUBLICATION BIAS
    PARMLEY, WW
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 24 (05) : 1424 - 1425
  • [20] Overcoming the limitations of current meta-analysis of randomised controlled trials
    Pogue, J
    Yusuf, S
    [J]. LANCET, 1998, 351 (9095) : 47 - 52