Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin

被引：91

作者：

Tasduq, SA ^{[1
]}

Peerzada, K ^{[1
]}

Koul, S ^{[1
]}

Bhat, R ^{[1
]}

Johri, RK ^{[1
]}

机构：

[1] CSIR, Div Pharmacol, Reg Res Lab, Jammu 180001, India

来源：

HEPATOLOGY RESEARCH | 2005年 / 31卷 / 03期

关键词：

anti-TB drugs; liver toxicity; silymarin;

D O I：

10.1016/j.hepres.2005.01.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In the present study, the biochemical manifestations of liver toxicity caused by co-administration of anti-TB drugs, rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), in a sub-chronic mode (12 weeks), were investigated. Significant alterations were revealed in (a) increased levels of alanine aminotrasferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and a high bilirubin content in serum; (b) elevated lipid peroxidation (LPO), intracellular calcium [Ca2+](i) and CYP4502EI activity in liver; and (c) decreased glutathione (GSH) content, glutathione peroxidase (GPx) and catalase activities in liver. Silymarin reversed these abnormal alterations. The biochemical changes were supported by histological observations. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：132 / 135

页数：4

共 17 条

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