Inhibition of IL-17A in atherosclerosis

被引：66

作者：

Cheng, Xiang ^{[1
]}

Taleb, Soraya ^{[2
,3
]}

Wang, Jun ^{[1
]}

Tang, Ting-Ting ^{[1
]}

Chen, Jian ^{[1
]}

Gao, Xing-Li ^{[1
]}

Yao, Rui ^{[1
]}

Xie, Jiang-Jiao ^{[1
]}

Yu, Xian ^{[1
]}

Xia, Ni ^{[1
]}

Yan, Xin-Xin ^{[1
]}

Nie, Shao-Fang ^{[1
]}

Liao, Meng-Yang ^{[1
]}

Cheng, Yan ^{[5
]}

Mallat, Ziad ^{[2
,3
,4
]}

Liao, Yu-Hua ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Lab Cardiovasc Immunol,Inst Cardiol, Wuhan 430022, Peoples R China

[2] INSERM, U970, F-75015 Paris, France

[3] Univ Paris 05, Paris Cardiovasc Res Ctr, F-75015 Paris, France

[4] Univ Cambridge, Div Cardiovasc Med, Cambridge, England

[5] Univ Penn, Sch Med, Inst Translat Med & Therapeut ITMAT, Philadelphia, PA 19104 USA

来源：

ATHEROSCLEROSIS | 2011年 / 215卷 / 02期

基金：

中国国家自然科学基金;

关键词：

IL-17A; Antibody; Bone marrow transplantation; Inflammation; Atherosclerosis; DEFICIENT MICE; CELLS;

D O I：

10.1016/j.atherosclerosis.2010.12.034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To determine the effects of interleukin (IL)-17A inhibition on experimental atherosclerosis. Methods and results: ApoE(-/-) mice were treated with either rat anti-mouse IL-17A, mouse anti-mouse IL-17A or isotype-matched control antibodies for 12 weeks (n = 8-10 per group). Ldlr(-/-) mice were transplanted with IL-17A-deficient or wild type bone marrow (n = 8 per group). Rat anti-mouse IL-17A treatment obviously reduced plaque size by 43% (p < 0.01) without evidence of reduced IL-17A signaling. In contrast, mouse anti-mouse IL-17A treatment and IL-17A deficiency in bone marrow cells did not alter lesion size despite significant reduction of IL-17A production. Conclusions: Inhibition of IL-17A signaling does not alter lesion development in Th1-biased C57BL/6 ApoE(-/-) and Ldlr(-/-) mice with already low levels of IL-17A production. Alteration of lesion development after repeated injections of rat anti-mouse IL-17A antibody in ApoE(-/-) mice could not be attributed to blockade of IL-17A signaling. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：471 / 474

页数：4

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