Structure and expression of Wnt13, a novel mouse Wnt2 related gene

被引：53

作者：

Zakin, LDJ

Mazan, S

Maury, M

Martin, N

Guénet, JL

Brûlet, P

机构：

[1] Inst Pasteur, CNRS, Unite Embryol Mol, URA 1947, F-75724 Paris 15, France

[2] Univ Paris Sud, Lab Biol Cellulaire 4, F-91405 Orsay, France

[3] Inst Pasteur, Unite Genet Mammiferes, F-75724 Paris 15, France

来源：

MECHANISMS OF DEVELOPMENT | 1998年 / 73卷 / 01期

关键词：

Wnt; brain development; mouse;

D O I：

10.1016/S0925-4773(98)00040-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified a novel mouse member of the Wnt family, Wnt13. Among mouse Wnt genes, Wnt13 is most closely related to Wnt2. Sequence comparisons and chromosomal localization strongly suggest that Wnt13, rather than Wnt2, is the mouse orthologue of both the human WNT13 and Xenopus XWnt2 genes. Wnt13 is expressed in the embryonic mesoderm during gastrulation. At later stages, transcripts are detected in the dorsal midline of the diencephalon and mesencephalon, the heart primordia, the periphery of the lung bud and the otic and optic vesicles. These data suggest that Wnt13 function might partially overlap with those of other Wnt genes in the cell signaling mechanisms controlling mesoderm specification during gastrulation and some aspects of brain, heart and lung formation. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：107 / 116

页数：10

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