On the site and mechanism of action of the anti-obesity effects of interleukin-6

被引：30

作者：

Jansson, JO ^{[1
]}

Wallenius, K

Wernstedt, I

Ohlsson, C

Dickson, SL

Wallenius, V

机构：

[1] Sahlgrens Univ Hosp, Div Endocrinol, Gothenburg, Sweden

[2] Univ Cambridge, Dept Physiol, Cambridge, England

来源：

GROWTH HORMONE & IGF RESEARCH | 2003年 / 13卷

关键词：

obesity; interleukin-6;

D O I：

10.1016/S1096-6374(03)00051-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We conducted an experimental study examining the site and mechanism of action of the anti-obesity effect of interleukin-6 (IL-6) in mice and rats. We used dual energy X-ray absorptiometry (DEXA) and computerized tomography to investigate the body composition of mice with knockout of the IL-6 gene and wild-type control mice. Rats were treated with IL-6 or vehicle through intracerebroventricular (ICV) cannulae. Energy expenditure was measured as oxygen consumption by indirect calorimetry in metabolic chambers. Results showed that the mice lacking IL-6 increased in body weight compared with wild-type mice from 6 months of age onward, although there was no marked difference in food intake between the pre-obese IL-6 knockout mice and the wild-type mice. IL-6 given as a single ICV injection to rats stimulated oxygen consumption; whereas, the same doses were ineffective when given peripherally. Chronic ICV IL-6 treatment decreased body weight and fat mass in rodents. Administration of IL-6 may decrease fat mass in mice and rats by stimulating energy expenditure at the CNS level, possibly in the hypothalamus. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：S28 / S32

页数：5

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