Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

被引：104

作者：

Fatmawati, Sri ^{[1
,2
]}

Shimizu, Kuniyoshi ^{[1
]}

Kondo, Ryuichiro ^{[1
]}

机构：

[1] Kyushu Univ, Dept Forest & Forest Prod Sci, Fac Agr, Fukuoka 8128581, Japan

[2] Sepuluh Nopember Inst Technol, Dept Chem, Fac Math & Nat Sci, Surabaya 60111, Indonesia

来源：

FITOTERAPIA | 2010年 / 81卷 / 08期

关键词：

Ganoderma lucidum; Aldose reductase inhibitor; Ganoderic acid; LIQUID-CHROMATOGRAPHY;

D O I：

10.1016/j.fitote.2010.06.025

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7 beta,11 beta-dihydroxy-3, 15, 23-trioxo-5 alpha-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 mu M in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active. (C) 2010 Elsevier B.V. All rights reserved.

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页码：1033 / 1036

页数：4

相关论文

共 11 条

[1]

Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum [J].

Akihisa, Toshihiro ;

Nakamura, Yuji ;

Tagata, Masaaki ;

Tokuda, Harukuni ;

Yasukawa, Ken ;

Uchiyama, Emiko ;

Suzuki, Takashi ;

Kimura, Yumiko .

CHEMISTRY & BIODIVERSITY, 2007, 4 (02) :224-231

[2]

El-Kabbani O, 1999, MOL VIS, V5, pU1

[3]

The Inhibitory Effect on Aldose Reductase by an Extract of Ganoderma lucidum [J].

Fatmawati, Sri ;

Kurashiki, Kenji ;

Takeno, Sayaka ;

Kim, Yong-ung ;

Shimizu, Kuniyoshi ;

Sato, Masao ;

Imaizumi, Katsumi ;

Takahashi, Kaori ;

Kamiya, Shinji ;

Kaneko, Shuhei ;

Kondo, Ryuichiro .

PHYTOTHERAPY RESEARCH, 2009, 23 (01) :28-32

[4]

Quantitative determination of bitter principles in specimens of Ganoderma lucidum using high-performance liquid chromatography and its application to the evaluation of Ganoderma products [J].

Gao, JJ ;

Nakamura, N ;

Min, BS ;

Hirakawa, A ;

Zuo, F ;

Hattori, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (06) :688-695

[5]

KINOSHITA JH, 1976, JPN J OPHTHALMOL, V20, P399

[6]

KOHDA H, 1985, CHEM PHARM BULL, V33, P1367

[7]

5α-Reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum [J].

Liu, J ;

Kurashiki, K ;

Shimizu, K ;

Kondo, R .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (02) :392-395

[8]

Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor [J].

Liu, Jie ;

Shiono, Jun ;

Shimizu, Kuniyoshi ;

Kukita, Akiko ;

Kukita, Toshio ;

Kondo, Ryuichiro .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (08) :2154-2157

[9]

PURIFICATION AND CHARACTERIZATION OF THE RECOMBINANT HUMAN ALDOSE REDUCTASE EXPRESSED IN BACULOVIRUS SYSTEM [J].

NISHIMURA, C ;

YAMAOKA, T ;

MIZUTANI, M ;

YAMASHITA, K ;

AKERA, T ;

TANIMOTO, T .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1078 (02) :171-178

[10]

Ganoderma -: A therapeutic fungal biofactory [J].

Russell, R. ;

Paterson, M. .

PHYTOCHEMISTRY, 2006, 67 (18) :1985-2001