Total synthesis, configuration, and biological evaluation of anguinomycin C

被引：53

作者：

Bonazzi, Simone

Guettinger, Stephan

Zemp, Ivo

Kutay, Ulrike ^{[1
]}

Gademann, Karl

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Chem Synthesis Lab, SB ISIC LSYNC, CH-1015 Lausanne, Switzerland

[2] ETH, Swiss Fed Inst Technol, Inst Biochem, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 45期

关键词：

antitumor agents; leptomycins; nuclear export; polyketides; total synthesis;

D O I：

10.1002/anie.200703134

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Against nuclear export! Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels-Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary. © 2007 Wiley-VCH Verlag GmbH S. Co. KGaA.

引用

页码：8707 / 8710

页数：4

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