First total synthesis of the antitumor compound (-)-kazusamycin A and absolute structure determination

被引:23
作者
Arai, N
Chikaraishi, N
Omura, S
Kuwajima, I
机构
[1] JST, CREST, Creat & Funct New Mol & Mol Assemblies, Sagamihara, Kanagawa 2288555, Japan
[2] Kitasato Univ, Kitasato Inst Life Sci, Sagamihara, Kanagawa 2288555, Japan
关键词
D O I
10.1021/ol049219z
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first total synthesis of kazusamycin A, a potent antitumor compound from an actinomycete, has been achieved, and its absolute structure was determined. Paterson's stereoselective aldol reaction was successfully applied to construct the contiguous chiral centers by using an originally designed optically active 2-acyl-1,3-propanediol derivative.
引用
收藏
页码:2845 / 2848
页数:4
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