Enantioselective preparation of asymmetrically protected 2-propanoyl-1,3-propanediol derivatives: toward the total synthesis of Kazusamycin A

被引：6

作者：

Arai, N

Chikaraishi, N

Ikawa, M

Omura, S

Kuwajima, I

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Kanagawa 2288555, Japan

[2] Japan Sci & Technol Agcy, CREST, Creat & Funct New Mol & Mol Assemblies, Kanagawa 2288555, Japan

[3] Kitasato Univ, Fac Sci, Dept Chem, Kanagawa 2288555, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.tetasy.2004.01.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation of enantiomerically pure 2-propanoyl-1,3-propanediol derivatives, key intermediates in our studies on total synthesis of the potent antitumor compound Kazusamycin A are described. After various enzymatic protocols for desymmetrization of the prochiral diol were studied, it was found that these compounds could be prepared in 97-98% ee by means of an enzymatic kinetic resolution. (C) 2004 Published by Elsevier Ltd.

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页码：733 / 741

页数：9

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