AID to overcome the limitations of genomic information

被引：81

作者：

Honjo, T ^{[1
]}

Nagaoka, H ^{[1
]}

Shinkura, R ^{[1
]}

Muramatsu, M ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Immunol & Genom Med, Sakyo Ku, Kyoto 6068501, Japan

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 07期

关键词：

D O I：

10.1038/ni1218

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The limitations of genomic information forced our ancestors to adopt a strategy for introducing somatic DNA alterations with the risk of genome instability. Although activation-induced deaminase ( AID) is involved in DNA cleavage in somatic hypermutation and class-switch recombination, its mechanism of action has been debated extensively, with the two main hypotheses being distinguished by the chief target of AID: RNA or DNA. The principle distinction between the two hypotheses is the requirement for translation of edited mRNA or uracil removal from DNA for DNA cleavage. Although a series of experiments has provided support for the `RNA-editing' hypothesis and requires reevaluation of the `DNA-deamination' hypothesis, definitive proof is yet to come.

引用

页码：655 / 661

页数：7

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