Evaluation of humoral response and protective efficacy of two inactivated vaccines against bluetongue virus after vaccination of goats

被引：44

作者：

Breard, E. ^{[1
]}

Belbis, G. ^{[2
]}

Hamers, C. ^{[3
]}

Moulin, V. ^{[4
]}

Lilin, T. ^{[5
]}

Moreau, F. ^{[5
]}

Millemann, Y. ^{[2
]}

Montange, C. ^{[3
]}

Sailleau, C. ^{[1
]}

Durand, B. ^{[6
]}

Desprat, A. ^{[1
]}

Viarouge, C. ^{[1
]}

Hoffmann, B. ^{[7
]}

de Smit, H. ^{[4
]}

Goutebroze, S. ^{[3
]}

Hudelet, P. ^{[3
]}

Zientara, S. ^{[1
]}

机构：

[1] ANSES, UMR Virol 1161, Lab Sante Anim, Maisons Alfort, France

[2] ENVA, Unite Pathol Betail, Maisons Alfort, France

[3] MERIAL SAS, St Vulbas, France

[4] Intervet Schering Plough Anim Hlth, Boxmeer, Netherlands

[5] ENVA, Ctr Rech Biomed, Maisons Alfort, France

[6] ANSES, Unite EPI, Lab Sante Anim, Maisons Alfort, France

[7] Inst Virusdiagnost, Greifswald, Germany

来源：

VACCINE | 2011年 / 29卷 / 13期

关键词：

Inactivated vaccine; Bluetongue virus; Serotype; 8; Goats; SHEEP; EPIDEMIOLOGY; CHALLENGE; INFECTION; STRAIN;

D O I：

10.1016/j.vaccine.2010.12.105

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bluetongue serotype 8 has become a major animal health issue in the European Union and the European member States have agreed on a vaccination strategy, which involves only inactivated vaccines. In this study, the efficacy of two inactivated vaccines against bluetongue virus serotype 8 (BTV-8) used in Europe since 2008, BTVPUR ALSAP (R) 8 (MERIAL) and BOVILIS (R) BTV8 (Intervet/SP-AH), was evaluated in goats immunized and challenged with BTV-8 field isolates under experimental conditions. Serological, virological and clinical examinations were conducted before and after challenge. Three groups of 10 goats each (groups A, B and C) were randomly constituted and 2 groups (A and C) were subcutaneously vaccinated twice with one dose of the two commercial vaccines BTVPUR ALSAP 8 (group A) or BOVILIS BTV8 (group C) respectively. Animals of the groups A, C and B (B: controls) were challenged with a virulent inoculum containing BTV-8. During the experiment, it was found out that the BTV-8 challenge inoculum was contaminated with another BTV serotype. However, results demonstrated that vaccination of goats with two injections of BTVPUR ALSAP 8 or BOVILIS BTV8 provided a significant clinical protection against a BTV-8 challenge and completely prevented BTV-8 viraemia in all vaccinated animals. Qualitative data showed no difference in the kinetics and levels of the humoral response induced by these two inactivated vaccines. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2495 / 2502

页数：8

共 29 条

[1] Clinical signs of bluetongue virus serotype 8 infection in sheep and goats [J].

Backx, A. ;

Heutink, C. G. ;

Van Rooij, E. M. A. ;

van Rijn, P. A. .

VETERINARY RECORD, 2007, 161 (17) :591-593

[2]

BATRAM DJ, VET J

[3] Bluetongue virus in the French Island of Reunion [J].

Bréard, E ;

Sailleau, C ;

Hamblin, C ;

Zientara, S .

VETERINARY MICROBIOLOGY, 2005, 106 (3-4) :157-165

[4] The epidemiology and diagnosis of bluetongue with particular reference to Corsica [J].

Breard, E ;

Hamblin, C ;

Hammoumi, S ;

Sailleau, C ;

Dauphin, G ;

Zientara, S .

RESEARCH IN VETERINARY SCIENCE, 2004, 77 (01) :1-8

[5]

Calistri P, 2004, VETER ITAL SER, V40, P243

[6] Emergence of Bluetongue Serotypes in Europe, Part 2: The Occurrence of a BTV-11 Strain in Belgium [J].

De Clercq, K. ;

Mertens, P. ;

De Leeuw, I. ;

Oura, C. ;

Houdart, P. ;

Potgieter, A. C. ;

Maan, S. ;

Hooyberghs, J. ;

Batten, C. ;

Vandemeulebroucke, E. ;

Wright, I. M. ;

Maan, N. ;

Riocreux, F. ;

Sanders, A. ;

Vanderstede, Y. ;

Nomikou, K. ;

Raemaekers, M. ;

Bin-Tarif, A. ;

Shaw, A. ;

Henstock, M. ;

Breard, E. ;

Dubois, E. ;

Gastaldi-Thiery, C. ;

Zientara, S. ;

Verheyden, B. ;

Vandenbussche, F. .

TRANSBOUNDARY AND EMERGING DISEASES, 2009, 56 (9-10) :355-361

[7] Efficacy of three inactivated vaccines against bluetongue virus serotype 8 in sheep [J].

Eschbaumer, Michael ;

Hoffmann, Bernd ;

Koenig, Patricia ;

Teifke, Jens P. ;

Gethmann, Joern M. ;

Conraths, Franz J. ;

Probst, Carolina ;

Mettenleiter, Thomas C. ;

Beer, Martin .

VACCINE, 2009, 27 (31) :4169-4175

[8] Comparative safety study of three inactivated BTV-8 vaccines in sheep and cattle under field conditions [J].

Gethmann, J. ;

Huettner, K. ;

Heyne, H. ;

Probst, C. ;

Ziller, M. ;

Beer, M. ;

Hoffmann, B. ;

Mettenleiter, T. C. ;

Conraths, F. J. .

VACCINE, 2009, 27 (31) :4118-4126

[9]

Giovannini A., 2003, J RISK ANAL, V24, P1737

[10] Protective duration of immunity of an inactivated bluetongue (BTV) serotype 2 vaccine against a virulent BTV serotype 2 challenge in sheep [J].

Hamers, C. ;

Rehbein, S. ;

Hudelet, P. ;

Blanchet, M. ;

Lapostolle, B. ;

Cariou, C. ;

Duboeuf, M. ;

Goutebroze, S. .

VACCINE, 2009, 27 (21) :2789-2793

← 1 2 3 →