Catecholamine receptor polymorphisms affect decision-making in C. elegans

被引:134
作者
Bendesky, Andres [1 ]
Tsunozaki, Makoto [1 ]
Rockman, Matthew V. [2 ,3 ]
Kruglyak, Leonid [4 ,5 ]
Bargmann, Cornelia I. [1 ]
机构
[1] Rockefeller Univ, Howard Hughes Med Inst, Lab Neural Circuits & Behav, New York, NY 10065 USA
[2] New York Univ, Dept Biol, New York, NY 10003 USA
[3] New York Univ, Ctr Genom & Syst Biol, New York, NY 10003 USA
[4] Princeton Univ, Howard Hughes Med Inst, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
[5] Princeton Univ, Dept Ecol & Evolutionary Biol, Carl Icahn Lab, Princeton, NJ 08544 USA
关键词
QUANTITATIVE TRAIT LOCUS; CARBON-DIOXIDE AVOIDANCE; DEPENDENT PROTEIN-KINASE; CAENORHABDITIS-ELEGANS; PHEROMONE ATTRACTION; NATURAL VARIATION; SOCIAL-BEHAVIOR; OCTOPAMINE; TYRAMINE; NEURONS;
D O I
10.1038/nature09821
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Innate behaviours are flexible: they change rapidly in response to transient environmental conditions, and are modified slowly by changes in the genome. A classical flexible behaviour is the exploration-exploitation decision, which describes the time at which foraging animals choose to abandon a depleting food supply. We have used quantitative genetic analysis to examine the decision to leave a food patch in Caenorhabditis elegans. Here we show that patch-leaving is a multigenic trait regulated in part by naturally occurring non-coding polymorphisms in tyra-3 (tyramine receptor 3), which encodes a G-protein-coupled catecholamine receptor related to vertebrate adrenergic receptors. tyra-3 acts in sensory neurons that detect environmental cues, suggesting that the internal catecholamines detected by tyra-3 regulate responses to external conditions. These results indicate that genetic variation and environmental cues converge on common circuits to regulate behaviour, and suggest that catecholamines have an ancient role in regulating behavioural decisions.
引用
收藏
页码:313 / U207
页数:7
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