Systemic inflammation increases shear stress-induced platelet plug formation measured by the PFA-100

被引：55

作者：

Homoncik, M

Blann, AD

Hollenstein, U

Pernerstorfer, T

Eichler, HG

Jilma, B

机构：

[1] Univ Hosp Vienna, Sch Med, Dept Clin Pharmacol TARGET, Vienna, Austria

[2] City Hosp, Univ Dept Med, Haemostasis Thrombosis & Vasc Biol Unit, Birmingham, W Midlands, England

[3] Univ Hosp Vienna, Sch Med, Dept Internal Med 1, Vienna, Austria

[4] Hanusch Hosp, Dept Anaesthesiol & Crit Care, Vienna, Austria

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 111卷 / 04期

关键词：

randomized controlled trial; platelet function; PFA-100; VWF inflammation;

D O I：

10.1046/j.1365-2141.2000.02473.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The PFA-100 measures platelet plug formation under shear stress and is strongly dependent on von Willebrand Factor (VWF) levels in plasma. We therefore hypothesized that elevated VWF levels, possibly as a result of acute inflammation, adversely influence PFA-100 results. Healthy volunteers received either 2 ng/kg endotoxin or placebo in a randomized controlled trial. Four hours after endotoxin (but not placebo) infusion VWF levels increased by 85%, collagen epinephrine-induced closure time (CT) decreased by 47% and collagen ADP-CT decreased by 38% (P < 0.0001) respectively. In conclusion, systemic inflammation has a major impact on the results obtained by PFA 100 and may confound interpretation of platelet function.

引用

页码：1250 / 1252

页数：3

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