Life and death in the atherosclerotic plaque

被引:10
作者
Bennett, Martin R. [1 ]
机构
[1] Univ Cambridge, Cambridge, England
关键词
cell death; cell division; cell senescence; CELL-DEATH; PROLIFERATION; ATHEROGENESIS; PHAGOCYTOSIS; PROGRESSION; SENESCENCE; APOPTOSIS; AUTOPHAGY; TISSUE; AORTA;
D O I
10.1097/MOL.0b013e32833d2bfd
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
The complexity of processes involved in assaying changes in cell kinetics in atherosclerosis mean that we must move towards cumulative assays of cell proliferation, cell death and senescence that can be measured in the time frames over which atherosclerosis occurs, and for studies that selectively manipulate one of these processes in a single-cell type without affecting other processes.
引用
收藏
页码:422 / 426
页数:5
相关论文
共 20 条
[1]
Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice [J].
Bentzon, Jacob F. ;
Sondergaard, Claus S. ;
Kassem, Moustapha ;
Falk, Erling .
CIRCULATION, 2007, 116 (18) :2053-2061
[2]
Burke AP, 2001, CIRCULATION, V103, P934
[3]
Chung IM, 1998, AM J PATHOL, V152, P913
[4]
Cell death in the cardiovascular system [J].
Clarke, Murray ;
Bennett, Martin ;
Littlewood, Trevor .
HEART, 2007, 93 (06) :659-664
[5]
Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration [J].
Clarke, Murray C. H. ;
Littlewood, Trevor D. ;
Figg, Nichola ;
Maguire, Janet J. ;
Davenport, Anthony P. ;
Goddard, Martin ;
Bennett, Martin R. .
CIRCULATION RESEARCH, 2008, 102 (12) :1529-1538
[6]
Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1-Directed Inflammation Effects of Hyperlipidemia-Mediated Inhibition of Phagocytosis [J].
Clarke, Murray C. H. ;
Talib, Sara ;
Figg, Nichola L. ;
Bennett, Martin R. .
CIRCULATION RESEARCH, 2010, 106 (02) :363-U83
[7]
CRISBY M, 1996, ATHEROSCLEROSIS, V139, P17
[8]
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals [J].
Duewell, Peter ;
Kono, Hajime ;
Rayner, Katey J. ;
Sirois, Cherilyn M. ;
Vladimer, Gregory ;
Bauernfeind, Franz G. ;
Abela, George S. ;
Franchi, Luigi ;
Nunez, Gabriel ;
Schnurr, Max ;
Espevik, Terje ;
Lien, Egil ;
Fitzgerald, Katherine A. ;
Rock, Kenneth L. ;
Moore, Kathryn J. ;
Wright, Samuel D. ;
Hornung, Veit ;
Latz, Eicke .
NATURE, 2010, 464 (7293) :1357-U7
[9]
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation [J].
Fernandes-Alnemri, T. ;
Wu, J. ;
Yu, J-W ;
Datta, P. ;
Miller, B. ;
Jankowski, W. ;
Rosenberg, S. ;
Zhang, J. ;
Alnemri, E. S. .
CELL DEATH AND DIFFERENTIATION, 2007, 14 (09) :1590-1604
[10]
Dating Components of Human Atherosclerotic Plaques [J].
Goncalves, Isabel ;
Stenstrom, Kristina ;
Skog, Goran ;
Mattsson, Soren ;
Nitulescu, Mihaela ;
Nilsson, Jan .
CIRCULATION RESEARCH, 2010, 106 (06) :1174-1177