Cell death in the cardiovascular system

被引：51

作者：

Clarke, Murray

Bennett, Martin

Littlewood, Trevor

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 2QQ, England

[2] Univ Cambridge, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Cambridge CB2 2QQ, England

来源：

HEART | 2007年 / 93卷 / 06期

关键词：

D O I：

10.1136/hrt.2006.088203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell death is important for both development and tissue homeostasis in the adult. As such, it is tightly controlled and deregulation is associated with diverse pathologies; for example, regulated cell death is involved in vessel remodelling during development or following injury, but deregulated death is implicated in pathologies such as atherosclerosis, aneurysm formation, ischaemic and dilated cardiomyopathies and infarction. We describe the mechanisms of cell death and its role in the normal physiology and various pathologies of the cardiovascular system.

引用

收藏

页码：659 / 664

页数：6

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