Differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor nectin-2 and an entry receptor expressed in Chinese hamster ovary cells

被引：22

作者：

Zago, A ^{[1
]}

Spear, PG ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 17期

关键词：

D O I：

10.1128/JVI.77.17.9695-9699.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Amino acid differences at seven positions in the N termini of the glycoproteins D (gDs) specified by herpes simplex virus type 1 (HSV-1) and HSV-2 are largely responsible for the significantly higher cell fusion activity of HSV-2 gD with Chinese hamster ovary cells expressing human nectin-2 or only an endogenous hamster receptor.

引用

页码：9695 / 9699

页数：5

共 22 条

[21] A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus [J].

Warner, MS ;

Geraghty, RJ ;

Martinez, WM ;

Montgomery, RI ;

Whitbeck, JC ;

Xu, RL ;

Eisenberg, RJ ;

Cohen, GH ;

Spear, PG .

VIROLOGY, 1998, 246 (01) :179-189

[22] Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1 [J].

Yoon, M ;

Zago, A ;

Shukla, D ;

Spear, PG .

JOURNAL OF VIROLOGY, 2003, 77 (17) :9221-9231

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