AIDS virus-specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape

被引：46

作者：

Maness, Nicholas J.

Valentine, Laura E.

May, Gemma E.

Reed, Jason

Piaskowski, Shari M.

Soma, Taeko

Furlott, Jessica

Rakasz, Eva G.

Friedrich, Thomas C.

Price, David A.

Gostick, Emma

Hughes, Austin L.

Sidney, John

Sette, Alessandro

Wilson, Nancy A.

Watkins, David I. ^{[1
]}

机构：

[1] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA

[2] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53706 USA

[3] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[4] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA

[5] La Jolla Inst Allergy & Immunol, La Jolla, CA 92307 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2007年 / 204卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1084/jem.20071261

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptic major histocompatibility complex class I epitopes have been detected in several pathogens, but their importance in the immune response to AIDS viruses remains unknown. Here, we show that Mamu-B*17(+) simian immunodeficiency virus (SIV) mac239-infected rhesus macaques that spontaneously controlled viral replication consistently made strong CD8(+) T lymphocyte (CD8-TL) responses against a cryptic epitope, RHLAFKCLW (cRW9). Importantly, cRW9-specific CD8-TL selected for viral variation in vivo and effectively suppressed SIV replication in vitro, suggesting that they might play a key role in the SIV-specific response. The discovery of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope suggests that the AIDS virus-specific cellular immune response is likely far more complex than is generally assumed.

引用

页码：2505 / 2512

页数：8

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