Cytochrome-P450-dependent biotransformation of xenobiotics in human and rodent embryonic tissues

被引:36
作者
Juchau, MR [1 ]
Boutelet-Bochan, H [1 ]
Huang, Y [1 ]
机构
[1] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA
关键词
D O I
10.3109/03602539808996324
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Profound species differences and developmental stage differences as well as a lack of solid data prevent broad, sweeping generalizations in terms of statements that can be made concerning the prenatal expression of individual P450 isoforms. It is clear, however, that several of such isoforms are expressed at levels that can be toxicologically significant. At present, the greatest interest appears to be in P450s 1A1, 1B1, 2E1, and 3A7, each of which has been reported to be expressed at toxicologically significant levels or at least at potentially toxicologically significant levels during organogenesis. Reports of the expression of other P450 isoforms at later stages of gestation also have appeared in the recent literature.
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页码:541 / 568
页数:28
相关论文
共 120 条
[1]   DEVELOPMENTAL EXPRESSION OF 2 MEMBERS OF A NEW CLASS OF TRANSCRIPTION FACTORS .1. EXPRESSION OF ARYL-HYDROCARBON RECEPTOR IN THE C57BL/6N MOUSE EMBRYO [J].
ABBOTT, BD ;
BIRNBAUM, LS ;
PERDEW, GH .
DEVELOPMENTAL DYNAMICS, 1995, 204 (02) :133-143
[2]  
ANDERSON LM, 1989, IARC SCI PUBLICATION
[3]   ANALYSIS OF BIOTRANSFORMATION OF BENZO[A]PYRENE IN HUMAN FETAL AND PLACENTAL TISSUES WITH HIGH-PRESSURE LIQUID-CHROMATOGRAPHY [J].
BERRY, DL ;
ZACHARIAH, PK ;
SLAGA, TJ ;
JUCHAU, MR .
EUROPEAN JOURNAL OF CANCER, 1977, 13 (07) :667-675
[4]   TRANSPLACENTAL INDUCTION OF MIXED-FUNCTION OXYGENASES IN EXTRA-HEPATIC TISSUES BY "2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN [J].
BERRY, DL ;
SLAGA, TJ ;
WILSON, NM ;
ZACHARIAH, PK ;
NAMKUNG, MJ ;
BRACKEN, WM ;
JUCHAU, MR .
BIOCHEMICAL PHARMACOLOGY, 1977, 26 (15) :1383-1388
[5]   TRANSPLACENTAL INDUCTION OF CARCINOGEN HYDROXYLATING SYSTEMS WITH 2, 3,7,8-TETRACHLORODIBENZO-P-DIOXIN [J].
BERRY, DL ;
ZACHARIAH, PK ;
NAMKUNG, MJ ;
JUCHAU, MR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1976, 36 (03) :569-584
[6]   CONVERSION OF ESTRADIOL-17-BETA TO REACTIVE EMBRYOTOXIC INTERMEDIATES BY CYTOCHROME-P-450-DEPENDENT BIOACTIVATING SYSTEMS [J].
BEYER, BK ;
JUCHAU, MR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 145 (01) :402-407
[7]   BIOTRANSFORMATION, ESTROGENICITY, AND STEROID STRUCTURE AS DETERMINANTS OF DYSMORPHOGENIC AND GENERALIZED EMBRYOTOXIC EFFECTS OF STEROIDAL AND NONSTEROIDAL ESTROGENS [J].
BEYER, BK ;
STARK, KL ;
FANTEL, AG ;
JUCHAU, MR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1989, 98 (01) :113-127
[8]   CHARACTERISTICS OF INDUCED BENZPYRENE HYDROXYLASE ACTIVITY IN RAT FOETO-PLACENTAL UNIT [J].
BOGDAN, DP ;
JUCHAU, MR .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1970, 10 (01) :119-+
[9]   METABOLISM OF BENZO[A]PYRENE AND 7,12-DIMETHYLBENZ[A]ANTHRACENE IN CULTURED HUMAN-FETAL AORTIC SMOOTH-MUSCLE CELLS [J].
BOND, JA ;
KOCAN, RM ;
BENDITT, EP ;
JUCHAU, MR .
LIFE SCIENCES, 1979, 25 (05) :425-430
[10]  
BOND JA, 1980, POLYNUCLEAR AROMATIC