Cytochrome-P450-dependent biotransformation of xenobiotics in human and rodent embryonic tissues

被引:36
作者
Juchau, MR [1 ]
Boutelet-Bochan, H [1 ]
Huang, Y [1 ]
机构
[1] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA
关键词
D O I
10.3109/03602539808996324
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Profound species differences and developmental stage differences as well as a lack of solid data prevent broad, sweeping generalizations in terms of statements that can be made concerning the prenatal expression of individual P450 isoforms. It is clear, however, that several of such isoforms are expressed at levels that can be toxicologically significant. At present, the greatest interest appears to be in P450s 1A1, 1B1, 2E1, and 3A7, each of which has been reported to be expressed at toxicologically significant levels or at least at potentially toxicologically significant levels during organogenesis. Reports of the expression of other P450 isoforms at later stages of gestation also have appeared in the recent literature.
引用
收藏
页码:541 / 568
页数:28
相关论文
共 120 条
[91]  
PELKONEN O, 1977, PROGR DRUG METABOLIS, V2, P119
[92]  
PELKONEN O, 1985, OCCUPATIONAL HAZARDS
[93]  
RANE A, 1973, CLIN PHARMACOL THER, V14, P666
[94]   THE EXPRESSION OF XENOBIOTIC-METABOLIZING CYTOCHROMES P450 IN FETAL TISSUES [J].
RAUCY, JL ;
CARPENTER, SJ .
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1993, 29 (03) :121-128
[95]   VALPROATE HYDROXYLATION BY HUMAN-FETAL TISSUES AND EMBRYOTOXICITY OF METABOLITES [J].
RETTIE, AE ;
RETTENMEIER, AW ;
BEYER, BK ;
BAILLIE, TA ;
JUCHAU, MR .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 40 (02) :172-177
[96]  
ROGERS JM, 1996, CASARAETT DOULLS TOX
[97]   SELECTIVE EXPRESSION OF CYTOCHROME-P450 CYP3A MESSENGER-RNAS IN EMBRYONIC AND ADULT HUMAN LIVER [J].
SCHUETZ, JD ;
BEACH, DL ;
GUZELIAN, PS .
PHARMACOGENETICS, 1994, 4 (01) :11-20
[98]  
Shepard TH, 1995, CATALOG TERATOGENIC
[99]  
Shimada T, 1996, DRUG METAB DISPOS, V24, P515
[100]  
Shimada T, 1996, CANCER RES, V56, P2979