Solvent-free benzylations of 2-pyridone. Regiospecific N- or C-alkylation

被引：33

作者：

Almena, I

DiazOrtiz, A

DiezBarra, E

delaHoz, A

Loupy, A

机构：

[1] UNIV CASTILLA LA MANCHA, FAC QUIM, DEPT QUIM ORGAN, E-13071 CIUDAD REAL, SPAIN

[2] UNIV PARIS 11, LAB REACT SELECT SUPPORTS, UA 478 CNRS, F-91405 ORSAY, FRANCE

来源：

CHEMISTRY LETTERS | 1996年 / 05期

关键词：

D O I：

10.1246/cl.1996.333

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Regiospecific N- or C-benzylations of 2-pyridone are observed in solvent-free conditions in the absence of base. The regioselectivity is controlled by the heating technique (microwave irradiation or conventional heating) or, using microwaves, by the emitted power or the leaving group of benzyl halides.

引用

页码：333 / 334

页数：2

共 12 条

[1] ABENHAIM D, 1994, HETEROCYCLES, V38, P793
[2] ABRAMOVITCH RA, 1991, ORG PREP PROCED INT, V23, P685
[3] ALMENA I, 1993, SYNTHETIC COMMUN, V24, P1057
[4] ALKYLATION OF POTASSIUM ACETATE IN DRY MEDIA THERMAL-ACTIVATION IN COMMERCIAL MICROWAVE-OVENS
BRAM, G
LOUPY, A
MAJDOUB, M
GUTIERREZ, E
RUIZHITZKY, E
[J]. TETRAHEDRON, 1990, 46 (15) : 5167 - 5176
[5] BRAM G, 1992, SOLID SUPPORTS CATAL, P302
[6] MICROWAVE-ASSISTED ORGANIC-REACTIONS
CADDICK, S
[J]. TETRAHEDRON, 1995, 51 (38) : 10403 - 10432
[7] SYNTHESIS OF 3-(1-ADAMANTYL)PYRAZOLE AND 3,5-DI(1-ADAMANTYL)PYRAZOLE IN A MICROWAVE-OVEN
FORFAR, I
CABILDO, P
CLARAMUNT, RM
ELGUERO, J
[J]. CHEMISTRY LETTERS, 1994, (11) : 2079 - 2080
[8] HERRADON B, 1995, SYNLETT, P455
[9] LOUPY A, 1992, NEW J CHEM, V16, P233
[10] APPLICATIONS OF MICROWAVE DIELECTRIC HEATING EFFECTS TO SYNTHETIC PROBLEMS IN CHEMISTRY
MINGOS, DMP
BAGHURST, DR
[J]. CHEMICAL SOCIETY REVIEWS, 1991, 20 (01) : 1 - 47

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