Cancer Genome Evolutionary Trajectories in Metastasis

被引：179

作者：

Birkbak, Nicolai J. ^{[1
,2
]}

McGranahan, Nicholas ^{[3
,4
]}

机构：

[1] Aarhus Univ, Dept Mol Med, Aarhus, Denmark

[2] Aarhus Univ, Bioinformat Res Ctr, Aarhus, Denmark

[3] UCL, Canc Res UK Lung Canc Ctr Excellence, Canc Inst, Paul OGorman Bldg,72 Huntley St, London WC1E 6BT, England

[4] UCL, Canc Genome Evolut Res Grp, Canc Inst, Paul OGorman Bldg,72 Huntley St, London WC1E 6BT, England

来源：

CANCER CELL | 2020年 / 37卷 / 01期

基金：

英国惠康基金; 奥地利科学基金会;

关键词：

GENETIC-HETEROGENEITY; EXTRACELLULAR-MATRIX; BRANCHED EVOLUTION; SOMATIC MUTATIONS; LANDSCAPE; INSTABILITY; PROGRESSION; RESISTANCE; HISTORY; TUMORS;

D O I：

10.1016/j.ccell.2019.12.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread.

引用

页码：8 / 19

页数：12

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