Genomic signature is preserved in short DNA fragments

被引：28

作者：

Deschavanne, P ^{[1
]}

Giron, A ^{[1
]}

Vilain, J ^{[1
]}

Dufraigne, C ^{[1
]}

Fertil, B ^{[1
]}

机构：

[1] CHU Pitie Salpetriere, INSERM U494, F-75634 Paris 13, France

来源：

IEEE INTERNATIONAL SYMPOSIUM ON BIO-INFORMATICS AND BIOMEDICAL ENGINEERING, PROCEEDINGS | 2000年

关键词：

D O I：

10.1109/BIBE.2000.889603

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

The Chaos Game Representation paradigm has been implemented to display the usage of short oligonucleotides in genomes under the form off,-actal images. These images can be considered as a genomic signature. Using an unsupervised classification approach, it is shown that short fragments of genomic sequences retain most Of the characteristics of the species they come from. It thus appeals possible to perform global comparison of species by means of genome fragments found in databases. The efficiency of this approach is evaluated as a function of size of fragments and length of oligonucleotides.

引用

页码：161 / 167

页数：7

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