Antiviral amentoflavone from Selaginella sinensis

被引：113

作者：

Ma, SC

But, PPH ^{[1
]}

Ooi, VEC

He, YH

Lee, SHS

Lee, SF

Lin, RC

机构：

[1] Chinese Univ Hong Kong, Dept Biol, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China

[3] Dalhousie Univ, Dept Microbiol, Halifax, NS, Canada

[4] Dalhousie Univ, Dept Immunol, Halifax, NS, Canada

[5] Natl Inst Control Pharmaceut & Biol Prod, Beijing, Peoples R China

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 03期

关键词：

Selaginella sinensis; amentoflavone; anti-RSV activity; HPLC;

D O I：

10.1248/bpb.24.311

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amentoflavone and three other flavonoids were isolated from the ethanol extract of Selaginella sinensis, Amentoflavone showed potent antiviral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 mug/ml. The contents of amentoflavone in nine species of Selaginella were determined by reversed-phase HPLC, S, sinensis showed a higher content of 1,13%.

引用

页码：311 / 312

页数：2

共 16 条

[1]

BLAIR E, 1998, ANTIVIR THER, P71

[2] Bioactive compounds from Celaenodendron mexicanum [J].

Camacho, MD ;

Mata, R ;

Castaneda, P ;

Kirby, GC ;

Warhurst, DC ;

Croft, SL ;

Phillipson, JD .

PLANTA MEDICA, 2000, 66 (05) :463-468

[3]

GALASSO GJ, 1997, ANTIVIRAL AGENTS HUM, P369

[4] YUCCA LEAF PROTEIN (YLP) STOPS THE PROTEIN-SYNTHESIS IN HSV-INFECTED CELLS AND INHIBITS VIRUS-REPLICATION [J].

HAYASHI, K ;

NISHINO, H ;

NIWAYAMA, S ;

SHIRAKI, K ;

HIRAMATSU, A .

ANTIVIRAL RESEARCH, 1992, 17 (04) :323-333

[5] Antifungal biflavones from Cupressocyparis leylandii [J].

Krauze-Baranowska, M ;

Cisowski, W ;

Wiwart, M ;

Madziar, B .

PLANTA MEDICA, 1999, 65 (06) :572-573

[6] ANTIVIRAL TRADITIONAL MEDICINES AGAINST HERPES-SIMPLEX VIRUS (HSV-1), POLIOVIRUS, AND MEASLES-VIRUS IN-VITRO AND THEIR THERAPEUTIC EFFICACIES FOR HSV-1 INFECTION IN MICE [J].

KUROKAWA, M ;

OCHIAI, H ;

NAGASAKA, K ;

NEKI, M ;

XU, HX ;

KADOTA, S ;

SUTARDJO, S ;

MATSUMOTO, T ;

NAMBA, T ;

SHIRAKI, K .

ANTIVIRAL RESEARCH, 1993, 22 (2-3) :175-188

[7] Antiviral activities of biflavonoids [J].

Lin, YM ;

Flavin, MT ;

Schure, R ;

Chen, FC ;

Sidwell, R ;

Barnard, DL ;

Huffman, JH ;

Kern, ER .

PLANTA MEDICA, 1999, 65 (02) :120-125

[8] In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora [J].

Lin, YM ;

Anderson, H ;

Flavin, MT ;

Pai, YHS ;

MataGreenwood, E ;

Pengsuparp, T ;

Pezzuto, JM ;

Schinazi, RF ;

Hughes, SH ;

Chen, FC .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (09) :884-888

[9]

LOBSTEIN GA, 1988, PLANTA MED, V54, P555

[10] ISOLATION OF AMENTOFLAVONE FROM GINKGO-BILOBA [J].

LOBSTEINGUTH, A ;

BRIANCONSCHEID, F ;

VICTOIRE, C ;

HAAGBERRURIER, M ;

ANTON, R .

PLANTA MEDICA, 1988, (06) :555-556

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