The Integrated Project ReProTect: A novel approach in reproductive toxicity hazard assessment

被引:60
作者
Hareng, L
Pellizzer, C
Bremer, S
Schwarz, M
Hartung, T
机构
[1] European Ctr Validat Alternat Methods, Joint Res Ctr, I-21020 Ispra, VA, Italy
[2] European Chem Bur, Joint Res Ctr, Ispra, Italy
[3] Univ Tubingen, Dept Toxicol, Inst Pharmacol & Toxicol, Tubingen, Germany
关键词
Integrated Project ReProTect; reproductive toxicity; ECVAM; developmental toxicity; hazard assessment;
D O I
10.1016/j.reprotox.2005.04.003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Validated alternative test methods are urgently needed for safety testing of drugs, chemicals and cosmetics. Whereas some animal tests for topical toxicity have been successfully replaced by alternative methods, systemic toxicity testing requires new test strategies in order to achieve an adequate safety level for the consumer. Substantial numbers of animals are required for the current in vivo assays for drugs, chemicals and cosmetics and a broad range of pioneering alternative methods were already developed. These prerequisites motivate the development of a tiered testing strategy based on alternative tests for reproductive toxicity hazard. In the Integrated Project ReProTect, a consortium set up by the European Centre for the Validation of Alternative Methods (ECVAM) takes the lead to manage the development of a testing strategy in the area of reproductive toxicity. The reproductive cycle can be broken down into well-defined sub-elements, namely male and female fertility, implantation and pre/postnatal development. In this project, in vitro, in silico and sensor technologies will be developed, leading to testing strategies, that shall be implemented and disseminated. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:441 / 452
页数:12
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