The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

被引：896

作者：

Doane, Tennyson L. ^{[1
]}

Burda, Clemens ^{[1
]}

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 07期

关键词：

METAL-ENHANCED FLUORESCENCE; MESOPOROUS SILICA NANOPARTICLES; RESPONSIVE CONTROLLED-RELEASE; SEMICONDUCTOR QUANTUM DOTS; GROWTH-FACTOR RECEPTOR; COATED GOLD NANOPARTICLES; IN-VIVO; PHOTODYNAMIC THERAPY; REAL-TIME; PHOTOTHERMAL THERAPY;

D O I：

10.1039/c2cs15260f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy, and review recent advances in major NP based biomedical applications. Critical questions of transport, uptake, and clearance will be discussed and illustrated through the success and opportunities of NP imaging and therapy on a photodynamic therapy (PDT) based NP system that has been developed in our lab over the past decade (540 references).

引用

页码：2885 / 2911

页数：27

共 542 条

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