Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles

被引：404

作者：

Agasti, Sarit S. ^{[1
]}

Chompoosor, Apiwat ^{[1
]}

You, Chang-Cheng ^{[1
]}

Ghosh, Partha ^{[1
]}

Kim, Chae Kyu ^{[1
]}

Rotello, Vincent M. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 16期

关键词：

MESOPOROUS SILICA; GUEST MOLECULES; CANCER-THERAPY; DELIVERY; RECOGNITION; ACTIVATION; DENDRONS; PRODRUGS; PEPTIDE; CELLS;

D O I：

10.1021/ja900591t

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

引用

页码：5728 / +

页数：3

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