Nanoparticle-mediated singlet oxygen generation from photosensitizers

被引：26

作者：

Clement, Sandhya ^{[1
]}

Sobhan, Mushtaq ^{[1
]}

Deng, Wei ^{[1
]}

Camilleri, Elizabeth ^{[1
]}

Goldys, Ewa M. ^{[1
]}

机构：

[1] Macquarie Univ, ARC Ctr Nanoscale BioPhoton CNBP, Sydney, NSW 2109, Australia

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2017年 / 332卷

基金：

澳大利亚研究理事会;

关键词：

Nanoparticle; Photosensitizer; Conjugation; Singlet oxygen; Electric field enhancement; Singlet oxygen quantum yiled; METAL-ENHANCED PHOSPHORESCENCE; PHOTODYNAMIC THERAPY; QUANTUM DOTS; VERTEPORFIN; MOLECULES; DESIGN; CANCER; PROBES; SENSOR;

D O I：

10.1016/j.jphotochem.2016.08.009

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

We report on the modification of the efficiency of singlet oxygen generation in photosensitizers conjugated to dielectric (CeF3) and metal (Au) nanoparticles in water. The conjugates were formed with two photosensitizers, verteporfin and Rose Bengal. Quantitative analysis of the singlet oxygen generation demonstrated that the conjugation of the photosensitizer to a nanoparticle increases the efficiency of the photosensitizers to produce singlet oxygen in water. The singlet oxygen quantum yield of UV-sensitized verteporfin increases by a factor of 1.45 and 1.64 for CeF3-verteporfin and Au-verteporfin conjugates respectively compared to unconjugated verteporfin. Furthermore, Au-Rose Bengal conjugates also demonstrated enhanced singlet oxygen yield when sensitized at the plasmonic wavelength of 532 nm. We quantitatively explain these findings by the electric field enhancements around the nanoparticles. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：66 / 71

页数：6

共 36 条

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