Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation

被引：217

作者：

De Petrocellis, L. ^{[4
]}

Orlando, P. ^{[2
]}

Moriello, A. Schiano ^{[4
]}

Aviello, G. ^{[3
]}

Stott, C. ^{[5
]}

Izzo, A. A. ^{[3
]}

Di Marzo, V. ^{[1
]}

机构：

[1] CNR, Inst Biomol Chem, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy

[2] Univ Naples Federico 2, Endocannabinoid Res Grp, Inst Prot Biochem, Naples, Italy

[3] Univ Naples Federico 2, Dept Expt Pharmacol, Endocannabinoid Res Grp, Naples, Italy

[4] CNR, Inst Cybernet, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy

[5] GW Pharmaceut Ltd, Salisbury, Wilts, England

来源：

ACTA PHYSIOLOGICA | 2012年 / 204卷 / 02期

关键词：

cannabinoids; endocannabinoids; intestine; receptor; TRP channels; NEUROPATHIC PAIN; RAT MODEL; RECEPTOR; CANNABIDIOL; SATIVA; MICE; DESENSITIZATION; CONSTITUENT; HYDROLYSIS; MECHANISMS;

D O I：

10.1111/j.1748-1716.2011.02338.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Aim: Plant cannabinoids, like ?9-tetrahydrocannabinol (THC) and cannabidiol (CBD), activate/desensitize thermosensitive transient receptor potential (TRP) channels of vanilloid type-1 or -2 (TRPV1 or TRPV2). We investigated whether cannabinoids also activate/desensitize two other thermo-TRPs, the TRP channels of vanilloid type-3 or -4 (TRPV3 or TRPV4), and if the TRPV-inactive cannabichromene (CBC) modifies the expression of TRPV14 channels in the gastrointestinal tract.

引用

页码：255 / 266

页数：12

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