Syntheses of 5-hexadecanolide, 6-acetoxy-5-hexadecanolide and tanikolide

被引：7

作者：

Chang, MY ^{[1
]}

Lin, CL ^{[1
]}

Chen, ST ^{[1
]}

机构：

[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2001年 / 48卷 / 04期

关键词：

D O I：

10.1002/jccs.200100112

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total syntheses of 5-hexadecanolide (1), 6-acetoxy-5-hexadecanolide (2) and tanikolide (3) are described. 1-Bromoundecane (4) and 5-benzyl-1-pentanal (5) were chosen as starting materials. Wittig olefination and Grignard addition 4 and 5 afforded the 16-carbon skeleton, which underwent a series of functional group transformations to give delta -lactone derivatives 1, 2 and 3.

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页码：787 / 794

页数：8

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