Rap1 signalling: Adhering to new models

被引：516

作者：

Bos, JL

de Rooij, J

Reedquist, KA

机构：

[1] Univ Utrecht, Med Ctr, Dept Physiol Chem, NL-3584 CG Utrecht, Netherlands

[2] Univ Utrecht, Med Ctr, Ctr Biomed Genet, NL-3584 CG Utrecht, Netherlands

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 05期

关键词：

D O I：

10.1038/35073073

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1, the closest relative of Ras, has attracted much attention because of the possibility that it regulates Ras-mediated signalling. Rap1 is activated by extracellular signals through several regulatory proteins, and it might function in diverse processes, ranging from modulation of growth and differentiation to secretion, integrin-mediated cell adhesion and morphogenesis.

引用

收藏

页码：369 / 377

页数：9

相关论文

共 98 条

[81] The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum [J].

Seastone, DJ ;

Zhang, LY ;

Buczynski, G ;

Rebstein, P ;

Weeks, G ;

Spiegelman, G ;

Cardelli, J .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (02) :393-406

[82] Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase [J].

Sidovar, MF ;

Kozlowski, P ;

Lee, JW ;

Collins, MA ;

He, YQ ;

Graves, LM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (37) :28688-28694

[83]

Tanaka Y, 1999, J IMMUNOL, V163, P6209

[84] The Ras target AF-6 is a substrate of the Fam deubiquitinating enzyme [J].

Taya, S ;

Yamamoto, T ;

Kano, K ;

Kawano, Y ;

Iwamatsu, A ;

Tsuchiya, T ;

Tanaka, K ;

Kanai-Azuma, M ;

Wood, SA ;

Mattick, JS ;

Kaibuchi, K .

JOURNAL OF CELL BIOLOGY, 1998, 142 (04) :1053-1062

[85] Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion [J].

Tsukamoto, N ;

Hattori, M ;

Yang, HL ;

Bos, JL ;

Minato, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18463-18469

[86] Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A [J].

Tsygankova, OM ;

Saavedra, A ;

Rebhun, JF ;

Quilliam, LA ;

Meinkoth, JL .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (06) :1921-1929

[87] The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration [J].

Uemura, N ;

Griffin, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (53) :37525-37532

[88] cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway [J].

Vossler, MR ;

Yao, H ;

York, RD ;

Pan, MG ;

Rim, CS ;

Stork, PJS .

CELL, 1997, 89 (01) :73-82

[89] IDENTIFICATION OF TUBERIN, THE TUBEROUS SCLEROSIS-2 PRODUCT - TUBERIN POSSESSES SPECIFIC RAP1GAP ACTIVITY [J].

WIENECKE, R ;

KONIG, A ;

DECLUE, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (27) :16409-16414

[90] INHIBITION OF THE EGF-ACTIVATED MAP KINASE SIGNALING PATHWAY BY ADENOSINE-3',5'-MONOPHOSPHATE [J].

WU, J ;

DENT, P ;

JELINEK, T ;

WOLFMAN, A ;

WEBER, MJ ;

STURGILL, TW .

SCIENCE, 1993, 262 (5136) :1065-1069

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