How are the cellular functions of myosin V1 regulated within the cell?

被引：71

作者：

Buss, Folma ^{[2
]}

Kendrick-Jones, John ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 2XY, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 369卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

motor proteins; myosin VI; actin; cytoskeleton; PtdIns(4,5)P-2; membrane trafficking; myosin phosphorylation; optineurin; Dab2; GIPC;

D O I：

10.1016/j.bbrc.2007.11.150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review, dedicated to the memory of Professor Setsuro Ebashi, focuses on our current work investigating the cellular functions and regulation of the unique unconventional motor, myosin VI. This myosin, unlike all the other myosins so far studied, moves towards the minus end of actin filaments and has been implicated in a wide range of cellular processes such as endocytosis, exocytosis, cell migration, cell division and cytokinesis. Myosin VI's involvement in these cellular pathways is mediated by its interaction with specific adaptor proteins and is regulated by multiple regulatory signals and modifications such as calcium ions, PtdIns(4,5)P-2 (PIP2) and phosphorylation. Understanding the functions of myosin VI within the cell and how it is regulated is now of utmost importance given the recent observations that it is associated with a number of human disorders such as deafness and cancers. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：165 / 175

页数：11

共 106 条

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