Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells

被引：28

作者：

Batliner, Jasmin

Buehrer, Emanuel

Fey, Martin F. ^{[2
]}

Tschan, Mario P. ^{[1
,2
]}

机构：

[1] Univ Bern, Expt Oncol Hematol MEM E829, Dept Clin Res, CH-3010 Bern, Switzerland

[2] Univ Hosp Bern, Inselspital, Dept Med Oncol, CH-3010 Bern, Switzerland

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 02期

关键词：

miR-145; Acute myeloid leukemia (AML); Acute promyelocytic leukemia (APL); p73; Neutrophil; P53; LEUKEMIA; MICRORNA; CANCER;

D O I：

10.1016/j.leukres.2011.10.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MicroRNAs can influence hematopoietic cell lineage commitment and aberrant expression of hematopoietic miRNAs contributes to AML pathology. We found that miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. Further analysis revealed impaired neutrophil differentiation of APL cells upon inhibition of miR-145 expression. Lastly, we identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells. Our data suggest that low miR-145 levels in APL, possibly due to aberrant expression of p73 transcription factors, contribute to the differentiation block seen in this disease. (C) 2011 Elsevier Ltd. All rights reserved.

引用

收藏

页码：237 / 240

页数：4

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