Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum:: A new class of potent anti-HIV agents

被引：58

作者：

Duan, HQ

Takaishi, Y

Bando, M

Kido, M

Imakura, Y

Lee, KH

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Otsuka Pharmaceut Co Ltd, Tokushima 77101, Japan

[3] Naruto Univ Educ, Fac Sci, Tokushima 7728502, Japan

[4] Univ N Carolina, Sch Pharm, Natl Prod Lab, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(99)00339-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new sesquiterpene polyol esters (triptonine A and B) with alkaloid and monoterpene were isolated from Tripterygium hypoglaucum (Levl.) Hutch. Their structures were elucidated by spectroscopic means and X-ray analysis. Triptonine A (1) and hypoglaunine B-3) (4) demonstrated potent anti-HIV activity with EC50 values of 2.54 and 0.13 mu g/ml and therapeutic index values of 39.4 and >1000, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2969 / 2972

页数：4

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