Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum:: A new class of potent anti-HIV agents

被引:58
作者
Duan, HQ
Takaishi, Y
Bando, M
Kido, M
Imakura, Y
Lee, KH
机构
[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan
[2] Otsuka Pharmaceut Co Ltd, Tokushima 77101, Japan
[3] Naruto Univ Educ, Fac Sci, Tokushima 7728502, Japan
[4] Univ N Carolina, Sch Pharm, Natl Prod Lab, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA
关键词
D O I
10.1016/S0040-4039(99)00339-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two new sesquiterpene polyol esters (triptonine A and B) with alkaloid and monoterpene were isolated from Tripterygium hypoglaucum (Levl.) Hutch. Their structures were elucidated by spectroscopic means and X-ray analysis. Triptonine A (1) and hypoglaunine B-3) (4) demonstrated potent anti-HIV activity with EC50 values of 2.54 and 0.13 mu g/ml and therapeutic index values of 39.4 and >1000, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2969 / 2972
页数:4
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