Induction heating studies of Fe3O4 magnetic nanoparticles capped with oleic acid and polyethylene glycol for hyperthermia

被引：308

作者：

Ghosh, Runa ^{[2
]}

Pradhan, Lina ^{[1
]}

Devi, Yensenbam Priyabala ^{[2
]}

Meena, S. S. ^{[3
]}

Tewari, R. ^{[4
]}

Kumar, Amit ^{[1
]}

Sharma, Sachil ^{[5
]}

Gajbhiye, N. S. ^{[5
]}

Vatsa, R. K. ^{[2
]}

Pandey, Badri N. ^{[1
]}

Ningthoujam, R. S. ^{[2
]}

机构：

[1] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, India

[2] Bhabha Atom Res Ctr, Div Chem, Bombay 400085, Maharashtra, India

[3] Bhabha Atom Res Ctr, Solid State Phys Div, Bombay 400085, Maharashtra, India

[4] Bhabha Atom Res Ctr, Mat Sci Div, Bombay 400085, Maharashtra, India

[5] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2011年 / 21卷 / 35期

关键词：

SURFACE MODIFICATION; CANCER-CELLS; MOSSBAUER; SIZE; CHEMOTHERAPY; TEMPERATURE; STABILITY;

D O I：

10.1039/c1jm10092k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Fe3O4 magnetic nanoparticles (Fe3O4-MN) capped with either oleic acid (Fe3O4-OA-MN) or polyethylene glycol (Fe3O4-PEG-MN) were prepared by a co-precipitation method. From X-ray diffraction studies, the average crystallite sizes of Fe3O4-MN, Fe3O4-OA-MN and Fe3O4-PEG-MN were found to be 12, 6 and 8 nm, respectively. A reduction in the agglomeration of particles was observed when the magnetic nanoparticles (MN) were capped with oleic acid (OA) and polyethylene glycol (PEG), as confirmed by a transmission electron microscopy study. Magnetization of these MN was almost zero at room temperature in the absence of an applied magnetic field, indicating their superparamagnetic behavior. Magnetization was lower and the superparamagnetic fraction was higher for Fe3O4-OA-MN and Fe3O4-PEG-MN compared to Fe3O4-MN studied using a Mossbauer spectrometer. Compared to the control, an increased killing (35%) was observed in human breast cancer cells (MCF7) after Fe3O4-OA-MN treatment, which was further enhanced (65%) under induction heating conditions. However, MCF7 cells treated with Fe3O4-MN or Fe3O4-PEG-MN showed 5-10% killing after induction heating. These results showed the characterization of MN with different lipophilicity and suggests their suitability for hyperthermia applications in cancer therapy.

引用

页码：13388 / 13398

页数：11

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