A bi-modal approach against cancer: Magnetic alginate nanoparticles for combined chemotherapy and hyperthermia

被引：47

作者：

Ciofani, Gianni ^{[1
]}

Riggio, Cristina ^{[1
]}

Raffa, Vittoria ^{[1
]}

Menciassi, Arianna ^{[1
,2
]}

Cuschieri, Alfred ^{[1
]}

机构：

[1] Scuola Super Sant Anna, I-56127 Pisa, Italy

[2] IIT, I-16163 Genoa, Italy

来源：

MEDICAL HYPOTHESES | 2009年 / 73卷 / 01期

关键词：

MICROSPHERES;

D O I：

10.1016/j.mehy.2009.01.031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The use of polymeric carriers containing dispersed magnetic nanocrystailline particles has attracted considerable interest in the medical field. In this paper, We propose an innovative nanotechnological platform for cancer therapy, based on highly magnetized, biodegradable, and biocompatible polymeric nanoparticles. Alginate magnetic nanoparticles were prepared by our group by an efficient emulsion/reticulation technique and tested as drug delivery system. Here, we present a potential application that combines, in a single nanovector, efficient targeting, overcoming of bio-barriers, drug delivery, and physical disruption of tumor tissues. (C) 2009 Elsevier Ltd. All rights reserved.

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收藏

页码：80 / 82

页数：3

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