Rig-1 a new member of Robo family genes exhibits distinct pattern of expression during mouse development

被引：21

作者：

Camurri, L ^{[1
]}

Mambetisaeva, E ^{[1
]}

Sundaresan, V ^{[1
]}

机构：

[1] Kings Coll London, MRC, Ctr Dev Neurobiol, Dept Mol Neurobiol, London SE1 1UL, England

来源：

GENE EXPRESSION PATTERNS | 2004年 / 4卷 / 01期

基金：

英国医学研究理事会;

关键词：

mouse embryo; Rig-1; Robo1/DUTT1; spinal cord;

D O I：

10.1016/S1567-133X(03)00142-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Robo genes encode a family of proteins that are the receptors for the midline repellent Slits and play a role in axon guidance. In addition to Robo1 and Robo2, Rig-1 has been recently identified in mouse as a novel member of the Robo1 family of proteins. As a first step in elucidating the role of Rig-1 during vertebrate development, we characterised the expression of Rig-1 by in situ hybridisation together with Robo1 and Robo2 in the spinal cord and other tissues of the mouse embryo. Our results show that Rig-1 has a dynamic pattern of expression in the developing CNS. In the spinal cord Rig-1 shows overlapping but distinct pattern of expression with Robo1 and Robo2. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：99 / 103

页数：5

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