Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex

被引:100
作者
Parikh, Vinay [1 ]
Man, Kingson [1 ]
Decker, Michael W. [2 ]
Sarter, Martin [1 ]
机构
[1] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA
[2] Abbott Labs, Neurosci Res, Abbott Pk, IL 60064 USA
关键词
nicotine; acetylcholine; ABT-089; glutamate; choline/glutamate-sensitive microelectrodes; cognition;
D O I
10.1523/JNEUROSCI.5251-07.2008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Because modulation of cortical cholinergic neurotransmission has been hypothesized to represent a necessary mechanism mediating the beneficial cognitive effects of nicotine and nicotinic acetylcholine receptor ( nAChR) subtype-selective agonists, we used choline-sensitive microelectrodes for the real-time measurement of ACh release in vivo, to characterize cholinergic transients evoked by nicotine and the alpha 4 beta 2(star)-selective nAChR partial agonist 2-methyl-3-(2-(S)-pyrrolindinylmethoxy) pyridine dihydrochloride (ABT-089), a clinically effective cognition enhancer. In terms of cholinergic signal amplitudes, ABT-089 was significantly more potent than nicotine in evoking ACh cholinergic transients. Moreover, cholinergic signals evoked by ABT-089 were characterized by faster signal rise time and decay rate. The nAChRantagonist mecamylamine attenuated the cholinergic signals evoked by either compound. Cholinergic signals evoked by ABT-089 were more efficaciously attenuated by the relatively beta 2(star)-selective nAChR antagonist dihydro-beta-erythroidine. The alpha 7 antagonist methyllycaconitine did not affect choline signal amplitudes but partly attenuated the relatively slow decay rate of nicotine-evoked cholinergic signals. Furthermore, the AMPA receptor antagonist DNQX as well as the NMDA receptor antagonist APV more potently attenuated cholinergic signals evoked by ABT-089. Using glutamate-sensitive microelectrodes to measure glutamatergic transients, ABT-089 was more potent than nicotine in evoking glutamate release. Glutamatergic signals were highly sensitive to tetrodotoxin-induced blockade of voltage-regulated sodium channels. Together, the present evidence indicates that compared with nicotine, ABT-089 evokes more potent and sharper cholinergic transients in prefrontal cortex. Glutamatergic mechanisms necessarily mediate the cholinergic effects of nAChR agonists in the prefrontal cortex.
引用
收藏
页码:3769 / 3780
页数:12
相关论文
共 71 条
[61]   More attention must be paid: The neurobiology of attentional effort [J].
Sarter, Martin ;
Gehring, William J. ;
Kozak, Rouba .
BRAIN RESEARCH REVIEWS, 2006, 51 (02) :145-160
[62]   Locally administered low nicotine-induced neurotransmitter changes in areas of cognitive function [J].
Shearman, E ;
Rossi, S ;
Sershen, H ;
Hashim, A ;
Lajtha, A .
NEUROCHEMICAL RESEARCH, 2005, 30 (08) :1055-1066
[63]  
SULLIVAN JP, 1997, J PHARMACOL EXP THER, V2, P3
[64]   5-FLUORONICOTINE, NORANHYDROECGONINE, AND PYRIDYL-METHYLPYRROLIDINE RELEASE ACETYLCHOLINE AND BIOGENIC-AMINES IN RAT CORTEX IN-VIVO [J].
SUMMERS, KL ;
LIPPIELLO, P ;
VERHULST, S ;
GIACOBINI, E .
NEUROCHEMICAL RESEARCH, 1995, 20 (09) :1089-1094
[65]   Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex [J].
Summers, KL ;
Kem, WR ;
Giacobini, E .
JAPANESE JOURNAL OF PHARMACOLOGY, 1997, 74 (02) :139-146
[66]   Effects of handling on extracellular levels of glutamate and other amino acids in various areas of the brain measured by microdialysis [J].
Timmennan, W ;
Cisci, G ;
Nap, A ;
de Vries, JB ;
Westerink, BHC .
BRAIN RESEARCH, 1999, 833 (02) :150-160
[67]   Nicotine enhancement of dopamine release by a calcium-dependent increase in the size of the readily releasable pool of synaptic vesicles [J].
Turner, TJ .
JOURNAL OF NEUROSCIENCE, 2004, 24 (50) :11328-11336
[68]  
ULUS IH, 1992, J PHARMACOL EXP THER, V261, P1122
[69]   Neuronal nicotinic receptor agonists for the treatment of attentioon-deficit/hyperactivity disorder: Focus on cognition [J].
Wilens, Timothy E. ;
Decker, Michael W. .
BIOCHEMICAL PHARMACOLOGY, 2007, 74 (08) :1212-1223
[70]   ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: Results of a pilot study [J].
Wilens, Timothy E. ;
Verlinden, Marleen H. ;
Adler, Lenard A. ;
Wozniak, Patricia J. ;
West, Scott A. .
BIOLOGICAL PSYCHIATRY, 2006, 59 (11) :1065-1070