Therapeutic applications of carbon monoxide-releasing molecules

被引：267

作者：

Motterlini, R ^{[1
]}

Mann, BE ^{[1
]}

Foresti, R ^{[1
]}

机构：

[1] Northwick Pk Inst Med Res, Vasc Biol Unit, Dept Surg Res, Harrow, Middx, England

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2005年 / 14卷 / 11期

关键词：

bilirubin; carbon monoxide; carbon monoxide-releasing molecules; cardiovascular disease; haem oxygenase-1; inflammation; kidney disease; oxidative stress; vasorelaxation;

D O I：

10.1517/13543784.14.11.1305

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Carbon monoxide (CO), which is formed in mammalian cells through the oxidation of haem by the enzyme haem oxygenase, actively participates in the regulation of key intracellular functions. Emerging evidence reveals that an increased generation of haem oxygenase-derived CO plays a critical role in the resolution of inflammatory processes and alleviation of cardiovascular disorders. The authors have identified a novel class of substances, CO-releasing molecules (CO-RMs), which are capable of exerting a variety of pharmacological activities via the liberation of controlled amounts of CO in biological systems. A wide range of CO carriers containing manganese (CORM-1), ruthenium (CORM-2 and -3), boron (CORM-A1) and iron (CORM-F3) are currently being investigated to tailor therapeutic approaches for the prevention of vascular dysfunction, inflammation, tissue ischaemia and organ rejection.

引用

页码：1305 / 1318

页数：14

共 124 条

[1] Heme oxygenase and the cardiovascular-renal system [J].

Abraham, NG ;

Kappas, A .

FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (01) :1-25

[2] Gas-generating systems in acute renal allograft rejection in the rat - Co-induction of heme oxygenase and nitric oxide synthase [J].

Agarwal, A ;

Kim, Y ;

Matas, AJ ;

Alam, J ;

Nath, KA .

TRANSPLANTATION, 1996, 61 (01) :93-98

[3] INDUCTION OF HEME OXYGENASE IN TOXIC RENAL INJURY - A PROTECTIVE ROLE IN CISPLATIN NEPHROTOXICITY IN THE RAT [J].

AGARWAL, A ;

BALLA, J ;

ALAM, J ;

CROATT, AJ ;

NATH, KA .

KIDNEY INTERNATIONAL, 1995, 48 (04) :1298-1307

[4] Synthesis and properties of boranocarbonate:: A convenient in situ CO source for the aqueous preparation of [99mTC(OH2)3(CO)3]+ [J].

Alberto, R ;

Ortner, K ;

Wheatley, N ;

Schibli, R ;

Schubiger, AP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (13) :3135-3136

[5] CARBONYL DERIVATIVES OF CHLORIDE DIMETHYL-SULFOXIDE RUTHENIUM(II) COMPLEXES - SYNTHESIS, STRUCTURAL CHARACTERIZATION, AND REACTIVITY OF RU(CO)(X)(DMSO)(4-X)CL-2 COMPLEXES (X=1-3) [J].

ALESSIO, E ;

MILANI, B ;

BOLLE, M ;

MESTRONI, G ;

FALESCHINI, P ;

TODONE, F ;

GEREMIA, S ;

CALLIGARIS, M .

INORGANIC CHEMISTRY, 1995, 34 (19) :4722-4734

[6] Ruthenium antimetastatic agents [J].

Alessio, E ;

Mestroni, G ;

Bergamo, A ;

Sava, G .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2004, 4 (15) :1525-1535

[7] Ultraviolet A (320-400 nm) modulation of ultraviolet B (290-320 nm)-induced immune suppression is mediated by carbon monoxide [J].

Allanson, M ;

Reeve, VE .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 124 (03) :644-650

[8] Biochemical and biophysical properties of the CO-sensing transcriptional activator CooA [J].

Aono, S .

ACCOUNTS OF CHEMICAL RESEARCH, 2003, 36 (11) :825-831

[9] Acute renal hemodynamic effects of dimanganese decacarbonyl and cobalt protoporphyrin [J].

Arregui, B ;

López, B ;

Salom, MG ;

Valero, F ;

Navarro, C ;

Fenoy, FJ .

KIDNEY INTERNATIONAL, 2004, 65 (02) :564-574

[10] ENDOTHELIAL-CELL HEME UPTAKE FROM HEME-PROTEINS - INDUCTION OF SENSITIZATION AND DESENSITIZATION TO OXIDANT DAMAGE [J].

BALLA, J ;

JACOB, HS ;

BALLA, G ;

NATH, K ;

EATON, JW ;

VERCELLOTTI, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9285-9289

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