Emergence of spontaneous rhythm disorders in self-assembled networks of heart cells

被引：36

作者：

Soen, Y ^{[1
]}

Cohen, N ^{[1
]}

Lipson, D ^{[1
]}

Braun, F ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel

来源：

PHYSICAL REVIEW LETTERS | 1999年 / 82卷 / 17期

关键词：

D O I：

10.1103/PhysRevLett.82.3556

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

A noninvasive optical recording technique is introduced to study the spontaneous contractile activity in self-assembled heart cell networks. Continuous monitoring throughout the lifetime of the network reveals spontaneous appearance of various rhythm disorders. Analysis of two typical patterns, namely, subharmonic structures and sudden alternations between two dominant rates, indicates the emergence of intrinsic pacemakers. A model of one or two slightly variable nonlinear oscillators, acting on an excitable element, is shown to reproduce the main experimental results.

引用

页码：3556 / 3559

页数：4

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