Multichannel mould processing of 3D structures from microporous coralline hydroxyapatite granules and chitosan support materials for guided tissue regeneration/engineering

被引：26

作者：

Baran, ET

Tuzlakoglu, K

Salgado, AJ

Reis, RL

机构：

[1] Univ Minho, Dept Polymer Engn, P-4800058 Guimaraes, Portugal

[2] Univ Minho, 3Bs Res Grp Biomat Biodegradables & Biomimet, P-4710057 Braga, Portugal

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2004年 / 15卷 / 02期

关键词：

D O I：

10.1023/B:JMSM.0000011818.85273.cd

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A three-dimensional composite material was produced from microporous coralline origin hydroxyapatite (HA) microgranules, chitosan fibers and chitosan membrane. Cylindrical HA microgranules were oriented along channel direction within multichannel mould space and aligned particles were supported with fibers and a chitosan membrane. The positive replica of mould channels was clasp fixed to produce thicker scaffolds. Light microphotographs of the developed complex structure showed good adhesion between the HA particles, the fibers and the supporting membrane. The composite material showed 88% (w/w) swelling in one hour and preserved the complex structure of the original material upon long-term incubation in physiological medium. MEM extract test of HA chitosan complex showed no cell growth inhibition and cell viability assay (NITS) indicated over 90% cell viability. (C) 2004 Kluwer Academic Publishers.

引用

页码：161 / 165

页数：5

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