Ru- and Pd-Catalysed Synthesis of 2-Arylfurans by One-Flask Heck Arylation/Oxidation

被引：32

作者：

Schmidt, Bernd ^{[1
]}

Geissler, Diana ^{[1
]}

机构：

[1] Univ Potsdam, Inst Chem Organ Synthesechem, D-14476 Golm, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 25期

关键词：

Diazonium salts; Palladium; C-C coupling; Heck coupling; Furans; Oxidation; Oxygen heterocycles; RING-CLOSING METATHESIS; CYCLIC ENOL ETHERS; TANDEM CATALYSIS; DIAZONIUM SALTS; O-HETEROCYCLES; RUTHENIUM; INHIBITION; CYCLOADDITIONS; DERIVATIVES; REACTIVITY;

D O I：

10.1002/ejoc.201100549

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,5-Disubstituted furans were synthesized by one-flask Heck arylation/oxidation sequences. The starting materials are 2-substituted 2,3-dihydrofurans, conveniently available by RCM/isomerization sequences, and arenediazonium salts. These react in ligand-free Heck reactions to afford 2,5-disub-stituted 2,5-dihydrofurans, which are oxidized to the corresponding furans without isolation or intermediate workup. The oxidation is conveniently achieved with chloranil or DDQ, depending on the substrate.

引用

页码：4814 / 4822

页数：9

共 53 条

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