Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat

被引：10

作者：

Amara, DA

Segu, L

Buhot, MC

机构：

[1] Univ Bordeaux 1, Cognit Neurosci Lab, CNRS, UMR 5106, F-33405 Talence, France

[2] INSERM, Steroides & Syst Nerveux U488, F-94276 Le Kremlin Bicetre, France

来源：

NEUROSCIENCE LETTERS | 2001年 / 310卷 / 01期

关键词：

5-HT1A; 5-HT1B; subiculum; hippocampus; CA1; autoradiography; ibotenic acid lesion; serotonin;

D O I：

10.1016/S0304-3940(01)02080-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cellular location of 5-HT1A and 5-HT1B binding sites in the hippocampus was investigated using a stereotaxic unilateral lesion of the CA1 field by ibotenic acid, followed by autoradiography on brain sections with the specific ligands [H-3]8-OH-DPAT and S-CM-G[I-125]TNH2, respectively. As compared to the contralateral side of the lesion, the ipsilateral side exhibited a decrease in the density of 5-HT1A binding sites in the strata oriens and radiatum of CA1, and of 5-HT1B binding sites in the dorsal subiculum and stratum oriens of CA1. The results demonstrate that 5-HT1A binding sites are located on dendrites whereas 5-HT1B binding sites are located on axon terminals of CA1 pyramidal cells. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：25 / 28

页数：4

共 18 条

[11] CHOLINERGIC TERMINALS IN RAT HIPPOCAMPUS POSSESS 5-HT1B RECEPTORS MEDIATING INHIBITION OF ACETYLCHOLINE-RELEASE [J].