A synthetic route to the alkaloids of the ervatamine group. First total synthesis of (+/-)-6-oxo-16-episilicine

被引：18

作者：

Bennasar, ML

Vidal, B

Bosch, J

机构：

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 24期

关键词：

D O I：

10.1039/cc9960002755

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general route to silicine-methuenine alkaloids, exemplified by. the synthesis of 6-oxo-16-episilicine, involving the nucleophilic addition of an acetylindole enolate to the pyridinium salt 2, methoxycarbonylation of the resulting 1,4-dihydropyridine, controlled catalytic hydrogenation, cyclization on the indole 3-position and further functional group manipulations, is reported.

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页码：2755 / 2756

页数：2

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