HIV-associated nephropathy patients with and without apolipoprotein L1 gene variants have similar clinical and pathological characteristics

被引:49
作者
Atta, Mohamed G. [1 ]
Estrella, Michelle M. [1 ]
Kuperman, Michael [2 ]
Foy, Matthew C. [1 ]
Fine, Derek M. [1 ]
Racusen, Lorraine C. [2 ]
Lucas, Gregory M. [1 ]
Nelson, George W.
Warner, Andrew C. [3 ]
Winkler, Cheryl A. [4 ]
Kopp, Jeffrey B. [5 ]
机构
[1] Johns Hopkins Med Ctr, Dept Med, Baltimore, MD USA
[2] Johns Hopkins Med Ctr, Dept Pathol, Baltimore, MD USA
[3] NCI, Pathol Histotechnol Lab, Lab Anim Sci Program, Frederick, MD 21701 USA
[4] SAIC Frederick Inc, Basic Sci Program Ctr Canc Res, NCI, Frederick, MD USA
[5] NIDDK, Kidney Dis Sect, NIH, Bethesda, MD USA
基金
美国国家卫生研究院;
关键词
APOL1; end-stage kidney disease; HIV-associated nephropathy; STAGE RENAL-DISEASE; LIPID-BINDING PROTEIN; AUTOPHAGIC CELL-DEATH; KIDNEY-DISEASE; INFECTED INDIVIDUALS; APOL1; VARIANTS; RISK; SUSCEPTIBILITY; PROGRESSION;
D O I
10.1038/ki.2012.111
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Recently, an association was found between nondiabetic kidney disease in African Americans and two independent sequence variants in the APOL1 gene, encoding apolipoprotein L1. In this study we determined the frequency of APOL1 risk variants in patients with biopsy-proven HIV-associated nephropathy (HIVAN) and distinctive pathological characteristics potentially driven by those risk variants. Among 76 patients with HIVAN, 60 were successfully genotyped for APOL1 G1 and G2 polymorphisms. In this cohort, 37 had two risk alleles, 18 were heterozygous, and 5 had neither risk variant. There were no differences in the pathological findings of HIVAN and the number of APOL1 risk alleles. Further, the progression to end-stage kidney disease or death did not differ by the number of risk alleles. Median renal survival was 9.3 months in patients with zero or one risk allele compared to 11.7 months in patients with two APOL1 risk alleles. Thus, our study suggests that although the majority of African-American patients with HIVAN have two APOL1 risk alleles other as yet unknown factors in the host, including genetic risk variants and environmental or viral factors, may influence the development of this disorder in those with zero or one APOL1 risk allele. Kidney International (2012) 82, 338-343; doi:10.1038/ki.2012.111; published online 11 April 2012
引用
收藏
页码:338 / 343
页数:6
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