4,4-Difluoro-1α,25-dihydroxyvitamin D3:: Analog to probe A-ring conformation in vitamin D-receptor complex

被引：17

作者：

Shimizu, M ^{[1
]}

Iwasaki, Y ^{[1
]}

Yamada, S ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Inst Med & Dent Engn, Chiyoda Ku, Tokyo 1010062, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 09期

关键词：

conformation; fluorine and compounds; NMR; vitamins;

D O I：

10.1016/S0040-4039(99)00030-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4,4-Difluoro-1 alpha,25-dihydroxyvitamin D-3 was synthesized from ergosterol and analysis of its F-19 NMR showed it to be a useful probe to analyze the receptor-bound A-ring conformation of vitamin D. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1697 / 1700

页数：4

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