Acne-associated syndromes: models for better understanding of acne pathogenesis

被引：74

作者：

Chen, W. ^{[1
]}

Obermayer-Pietsch, B. ^{[2
]}

Hong, J-B ^{[3
,4
]}

Melnik, B. C. ^{[5
]}

Yamasaki, O. ^{[6
]}

Dessinioti, C. ^{[7
]}

Ju, Q. ^{[8
]}

Liakou, A. I. ^{[9
,10
,11
,12
]}

Al-Khuzaei, S. ^{[1
,13
]}

Katsambas, A. ^{[7
]}

Ring, J. ^{[1
]}

Zouboulis, C. C. ^{[9
,10
,11
,12
]}

机构：

[1] Tech Univ Munich, Dept Dermatol & Allergy, Munich, Germany

[2] Med Univ Graz, Div Endocrinol & Nucl Med, Dept Internal Med, Graz, Austria

[3] Natl Taiwan Univ Hosp, Dept Dermatol, Taipei, Taiwan

[4] Yun Lin Branch, Taipei, Taiwan

[5] Univ Osnabruck, Dept Dermatol Environm Med & Hlth Theory, Osnabruck, Germany

[6] Okayama Univ, Dept Dermatol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[7] Univ Athens, Andreas Sygros Hosp, Dept Dermatol, Athens, Greece

[8] Shanghai Skin Dis & STD Hosp, Dept Dermatol, Shanghai, Peoples R China

[9] Dessau Med Ctr, Dept Dermatol, Dessau, Germany

[10] Dessau Med Ctr, Dept Venereol, Dessau, Germany

[11] Dessau Med Ctr, Dept Allergol, Dessau, Germany

[12] Dessau Med Ctr, Dept Immunol, Dessau, Germany

[13] Hamad Med Corp, Dept Dermatol & Venereol, Doha, Qatar

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2011年 / 25卷 / 06期

关键词：

acne; Apert syndrome; insulin resistance; PAPA syndrome; PCO syndrome; SAPHO syndrome; POLYCYSTIC-OVARY-SYNDROME; HAIR-AN SYNDROME; CONGENITAL ADRENAL-HYPERPLASIA; ANDROGEN EXCESS DISORDERS; OSTEITIS SAPHO SYNDROME; 13-CIS RETINOIC ACID; PYODERMA-GANGRENOSUM; PYOGENIC ARTHRITIS; SEBACEOUS GLAND; PAPA SYNDROME;

D O I：

10.1111/j.1468-3083.2010.03937.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Acne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities.

引用

页码：637 / 646

页数：10

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